AI Article Synopsis
- A new automated method for newborn screening using mass spectrometry can identify key metabolites in just 4 minutes per sample.
- Each sample undergoes a standardized process where deuterated internal standards are applied before extraction, ensuring consistent results.
- The method improves efficiency, reduces costs, and maintains high traceability in laboratory practices, though aspartic acid showed some variability in results.
Article Abstract
A new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each sample is treated in an automated and standardized workflow, where a mixture of deuterated internal standards is sprayed onto the sample before extraction. All compounds showed good linearity, and intra- and inter-day variation lies within the acceptance criteria (except for aspartic acid). The described workflow decreases analysis cost and labor while improving the sample traceability towards good laboratory practice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548895 | PMC |
| http://dx.doi.org/10.3390/ijns4010002 | DOI Listing |
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