Purpose Of The Review: Immunotherapy has emerged as a promising cancer treatment, however success in only select clinical indications underscores the need for novel approaches. Recently based vaccines have been developed to drive tumor specific T-cell responses. Here, we discuss recent preclinical studies using vaccines, innate immune pathways that influence T-cell priming, and new vaccine strategies in clinical trials.
Recent Findings: Recent studies indicate that in addition to inducing antigen specific T-cell responses, vaccines remodel the TME. In addition, several innate immune pathways influence adaptive immune responses to and modulating these pathways holds promise to enhance anti-tumor T-cell responses.
Summary: The interplay between innate and adaptive immune responses to is poorly understood. Understanding these interactions will facilitate the design of better anti-cancer vaccines and improved use of combination therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560980 | PMC |
| http://dx.doi.org/10.1007/s40588-019-00133-4 | DOI Listing |
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