Editorial: Phagocytosis: Molecular Mechanisms and Physiological Implications.

Front Immunol

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Published: June 2021

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533641PMC
http://dx.doi.org/10.3389/fimmu.2020.586918DOI Listing

Publication Analysis

Top Keywords

editorial phagocytosis
4
phagocytosis molecular
4
molecular mechanisms
4
mechanisms physiological
4
physiological implications
4
editorial
1
molecular
1
mechanisms
1
physiological
1
implications
1

Similar Publications

Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury.

Front Immunol

January 2025

Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Cells die by necrosis due to excessive chemical or thermal stress, leading to plasma membrane rupture, release of intracellular components and severe inflammation. The clearance of necrotic cell debris is crucial for tissue recovery and injury resolution, however, the underlying mechanisms are still poorly understood, especially . This study examined the role of complement proteins in promoting clearance of necrotic cell debris by leukocytes and their influence on liver regeneration.

View Article and Find Full Text PDF

Heightened cholesterol 25-hydroxylase expression in aged lung during .

Front Aging

December 2024

Department of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, United States.

Introduction: Alveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to . Changes in lipid metabolism in AM can alter cellular function and biology. Impaired metabolism can contribute to excessive lipid accumulation and pro-inflammatory signaling.

View Article and Find Full Text PDF

The Molecular Determinants of Erythrocyte Removal Impact the Development of Metabolic Dysfunction-Associated Steatohepatitis.

Endocr Metab Immune Disord Drug Targets

December 2024

Laboratory of Biochemistry, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

Metabolic dysfunction-associated steatohepatitis (MASH) is a major cause of a worldwide clinical and financial burden. Despite the tremendous efforts for untangling the molecular mechanisms, there is still a need for defining specific therapeutic targets. In this editorial, the author will focus on the role of erythrocyte death and hepatic erythrophagocytosis in MASH.

View Article and Find Full Text PDF

A sex-dependent role of Kv1.3 channels from macrophages in metabolic syndrome.

Front Physiol

November 2024

Departamento de Bioquímica y Biología Molecular y Fisiología, Universidad de Valladolid, Valladolid, Spain.

Article Synopsis
  • Coronary artery disease (CAD) is a leading cause of death and disability worldwide, particularly affecting patients with type 2 diabetes (T2DM) who experience worse outcomes due to inflammation and endothelial dysfunction.* ! -
  • The study investigates the role of K1.3 channel blockers in reducing intimal hyperplasia and improving metabolic dysfunction in a T2DM mouse model, focusing on the macrophage K1.3 channels as potential therapeutic targets.* ! -
  • Results indicate that K1.3 channel expression is increased in macrophages from T2DM mice, especially in females, but these channels primarily influence cell migration rather than metabolic function or phagocytosis.* !
View Article and Find Full Text PDF

Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii.

Commun Biol

November 2024

Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, the Australian National University, Canberra, Australian Capital Territory, Australia.

Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective treatment strategy, it is critical to better understand how an A. baumannii MDR bacterium interacts with its mammalian host.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!