Recently, we reported that Dahl salt-sensitive leptin receptor mutant (SSmutant) rats exhibit dyslipidemia and renal lipid accumulation independent of hyperglycemia that progresses to chronic kidney disease (CKD). Therefore, in the current study, we examined the effects of gemfibrozil, a lipid-lowering drug (200 mg/kg/day, orally), on the progression of renal injury in SS and SSmutant rats for 4 weeks starting at 12 weeks of age. Plasma triglyceride levels were markedly elevated in the SSmutant strain compared to SS rats (1193 ± 243 and 98 ± 16 mg/day, respectively). Gemfibrozil treatment only reduced plasma triglycerides in the SSmutant strain (410 ± 79 mg/dL). MAP was significantly higher in the SSmutant strain vs. SS rats at the end of the study (198 ± 7 vs. 165 ± 7 mmHg, respectively). Administration of gemfibrozil only lowered MAP in SSmutant rats (163 ± 8 mmHg). During the course of the study, proteinuria increased to 125 ± 22 mg/day in SS rats. However, proteinuria did not change in the SSmutant strain and remained near baseline (693 ± 58 mg/day). Interestingly, treatment with gemfibrozil increased the progression of proteinuria by 77% in the SSmutant strain without affecting proteinuria in SS rats. The renal injury in the SSmutant strain progressed to CKD. Moreover, the kidneys from SSmutant rats displayed significant glomerular injury with mesangial expansion and increased renal lipid accumulation and fibrosis compared to SS rats. Treatment with gemfibrozil significantly reduced glomerular injury and lipid accumulation and improved renal function. These data indicate that reducing plasma triglyceride levels with gemfibrozil inhibits hypertension and CKD associated with obesity in SSmutant rats.
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http://dx.doi.org/10.3389/fphys.2020.566403 | DOI Listing |
BMC Psychol
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Health Department of Kuala Lumpur and Putrajaya, Health office of Lembah Pantai District, Ministry of Health, Kuala Lumpur, Malaysia.
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View Article and Find Full Text PDFVet Res
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College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine coronavirus that was recently identified in southern China in 2017. At present, there is a lack of nationwide epidemiological investigations of the newly emerged SADS-CoV. Because Vietnam is geographically adjacent to southern China, many diseases have spread from China to Vietnam.
View Article and Find Full Text PDFPerioper Med (Lond)
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Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
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View Article and Find Full Text PDFBMC Microbiol
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BMC Microbiol
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