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Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.
Virol J
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, PR China.
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections. The Vero cell line has been widely used in vaccine production, particularly in the preparation of viral vaccines, including poliovirus vaccines and EV71 vaccines.
View Article and Find Full Text PDFThe Dermatologic Oral Examination: Navigating the Oral Dermatoses Map.
J Am Acad Dermatol
January 2025
Mayo Clinic Arizona, Department of Dermatology, Scottsdale, AZ, USA.
Traditionally, dermatological education emphasizes hair, skin and nails in its curriculum. There is a practice gap with regard to knowledge of normal oral mucosa variants, performance of the oral examination, and competence in diagnosing and treating oral mucosal disorders. The oral mucosa falls within the purview of dermatology.
View Article and Find Full Text PDFThe effect of hand and foot exercises on peripheral neuropathy and quality of life in women with breast cancer: a randomized controlled trial.
Support Care Cancer
January 2025
Midwifery Department, Gülhane Faculty of Health Science, University of Health Sciences, Ankara, Turkey.
Purpose: Peripheral neuropathy is one of the most devastating symptoms experienced by the patients. Supportive and holistic care interventions are crucial to help these patients. The aim of this study is to determine the effects of hand and foot exercises on chemotherapy-induced peripheral neuropathy and quality of life in women with breast cancer.
View Article and Find Full Text PDFPlatelet factor 4-derived C15 peptide broadly inhibits enteroviruses by disrupting viral attachment.
J Virol
January 2025
Department of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
Unlabelled: Platelet factor 4 (PF4) has been shown to regulate several viral infections. Our previous study demonstrated that PF4 inhibits the entry of enterovirus A 71 (EV71) and coxsackievirus A16 (CA16), which cause hand, foot, and mouth disease (HFMD). In this study, we report that PF4 also inhibits the circulating HFMD pathogen coxsackievirus A6 (CA6) and the re-emerging enterovirus D68 (EVD68).
View Article and Find Full Text PDFDiscovery of a broad-spectrum monoclonal antibody recognizing a conserved, linear epitope WFYDGYPT on VP1 protein of Enterovirus A species.
Virol J
December 2024
Wuhan Institute of Biological Products Co., Ltd.,, No.1 Huangjin Industrial Park Road, Jiangxia District, Wuhan, 430207, China.
Background: The hand, foot and mouth disease (HFMD) was caused by species of Enterovirus A and Enterovirus B in the Asian-Pacific region. Broad-spectrum monoclonal antibodies (mAb) that can bind multiple serotypes of enteroviruses have gradually become a research hotspot in the diagnosis, prevention and treatment of HFMD.
Methods: In this study, a mAb 1H4 was obtained using monoclonal antibody technology by immunizing purified virus particles of Coxsackievirus A5 (CV-A5).
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