Since the outbreak with novel corona virus in December 2019, a myriad of different neurological manifestations in patients with COVID-19 infection have been reported. We present a case of non-traumatic intracranial hemorrhage in the olfactory gyrus in a patient who tested positive for SARS-COV-2. The area of hemorrhage is not a common location for spontaneous hemorrhage. Given that loss of smell is considered a relatively common symptom of this pandemic, it is an intriguing association of COVID-19 and olfactory gyrus ICH for neurotropism of SARS-CoV2 for olfactory bulb and glia cells through nasal mucosa. Future studies will need to elucidate the exact mechanism of anosmia from COVID-19 and potential mechanisms leading to ICH.
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http://dx.doi.org/10.1016/j.jocn.2020.07.033 | DOI Listing |
Front Neurosci
January 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Capital Medical University, Beijing, China.
Purpose: To investigate the changes in cerebral hemispheric functional connections in patients with acute acquired concomitant esotropia (AACE) and their relationship with clinical manifestations, utilizing voxel-mirrored homotopic connectivity (VMHC).
Methods: A prospective, observational study was conducted involving 32 AACE patients and 31 age-, sex-, and education-matched healthy controls (HC). The resting-state functional magnetic resonance imaging (rs-fMRI) signals, binocular vision function, and psychometric scale scores were collected rs-fMRI data and structural image data were analyzed for VMHC, and a two-sample -test was used to analyze the differences in VMHC between groups.
Eur J Neurosci
January 2025
Department of Ear, Nose, and Throat, The First Affiliated of Soochow University, Suzhou, China.
This study aimed to investigate the topological properties of brain functional networks in patients with tinnitus of varying durations. A total of 51 tinnitus patients (divided into recent-onset tinnitus (ROT) and persistent tinnitus (PT) groups) and 27 healthy controls (HC) were recruited. All participants underwent resting-state functional MRI and audiological assessments.
View Article and Find Full Text PDFNeuroimage
January 2025
Chemical Senses and Mental Health Lab, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
Previous research has revealed that the insula, pallidum, thalamus, hippocampus, middle frontal gyrus, and supplementary motor area are activated during odor memory and that the performance of olfactory working memory is affected by the verbalization of odors. However, the neural mechanisms underlying olfactory working memory and the role of verbalization in olfactory working memory are not fully understood. Twenty-nine participants were enrolled in a study to complete olfactory and visual n-back tasks using high- and low-verbalizability stimuli while undergoing fMRI imaging.
View Article and Find Full Text PDFJ Neurochem
January 2025
Neurosciences and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
The adult central nervous system (CNS) hosts several niches, in which the neural stem and precursor cells (NPCs) reside. The subventricular zone (SVZ) lines the lateral brain ventricles and the subgranular zone (SGZ) is located in the dentate gyrus of the hippocampus. SVZ and SGZ NPCs replace neurons and glia in the homeostatic as well as diseased or injured states.
View Article and Find Full Text PDFDominance hierarchies are key to social organization in group-living species, requiring individuals to recognize their own and others' ranks. This is particularly complex for intermediate-ranking animals, who navigate interactions with higher- and lower-ranking individuals. Using in situ hybridization, we examined how the brains of intermediate-ranked mice in hierarchies respond to dominant and subordinate stimuli by labeling activity-induced immediate early genes and neuronal markers.
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