In this study, a novel viscosity measurement technique based on measuring the deflection of flexible (poly) dimethylsiloxane (PDMS) micropillars is presented. The experimental results show a nonlinear relationship between fluid viscosity and the deflection of micropillars due to viscoelastic properties of PDMS. A calibration curve, demonstrating this nonlinear relationship, is generated, and used to determine the viscosity of an unknown fluid. Using our method, viscosity measurements for Newtonian fluids (glycerol/water solutions) can be performed within 2-100 cP at shear rates γ = 60.5-398.4 s. We also measured viscosity of human whole blood samples (non-Newtonian fluid) yielding 2.7-5.1 cP at shear rates γ = 120-345.1 s, which compares well with measurements using conventional rotational viscometers (3.6-5.7 cP). With a sensitivity better than 0.5 cP, this method has the potential to be used as a portable microfluidic viscometer for real-time rheological studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aca.2020.07.039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of a Microfluidic Viscometer for Non-Newtonian Blood Analog Fluid Analysis.
Bioengineering (Basel)
December 2024
Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu City 300, Taiwan.
The incidence of stroke is on the rise globally. This affects one in every four individuals each year, underscoring the urgent need for early warning and prevention systems. The existing research highlights the significance of monitoring blood viscosity in stroke risk evaluations.
View Article and Find Full Text PDFPortable Microfluidic Viscometer for Formulation Development and in Situ Quality Control of Protein and Antibody Solutions.
Anal Chem
August 2024
ETH Zürich, Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, 8093 Zürich, Switzerland.
Viscosity of protein solutions is a critical product quality attribute for protein therapeutics such as monoclonal antibodies. Here we introduce a portable single-use analytical chip-based viscometer for determining the viscosity of protein solutions using low sample volumes of 10 μL. Through the combined use of a microfluidic viscometer, a smartphone camera for image capture, and an automated data processing algorithm for the calculation of the viscosity of fluids, we enable measurement of viscosity of multiple samples in parallel.
View Article and Find Full Text PDFMicrofluidic Rheology: An Innovative Method for Viscosity Measurement of Gels and Various Pharmaceuticals.
Gels
July 2024
Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary.
Measuring the viscosity of pharmaceutical dosage forms is a crucial process. Viscosity provides information about the stability of the composition, the release rate of the drug, bioavailability, and, in the case of injectable drug formulations, even the force required for injection. However, measuring viscosity is a complex task with numerous challenges, especially for non-Newtonian materials, which include most pharmaceutical formulations, such as gels.
View Article and Find Full Text PDFOptoelectronic microfluidic device for point-of-care blood plasma viscosity measurement.
Lab Chip
June 2024
Department of Fundamental, Prophylactic and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania.
Physical properties of blood plasma, such as viscosity, serve as crucial indicators of disease. The inherent capillary effect of paper microchannels, coupled with minimal sample requirement, stimulated the advancement of paper-based viscometers. This study presents a precise, non-contact optoelectronic system using a microfluidic platform for the measurement of blood plasma viscosity.
View Article and Find Full Text PDFExperimental Performance Evaluation and Optimization of a Weak Gel Deep-Profile Control System for Sandstone Reservoirs.
ACS Omega
February 2024
Graduate School of International Resource Sciences, Department of Earth Resource Engineering and Environmental Science, Akita University, 1-1 Tegata Gakuen-machi, Akita 010-8502, Japan.
Globally, most oil fields use excessive water flooding to recover oil. By injection of water between wells, channels are created, which result in lower oil recovery. Water-plugging deep-profile control must be used to control the excessive water production from an oil reservoir.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!