AI Article Synopsis
- - The study aimed to explore how the severity of cognitive impairment after a stroke (PSCI) relates to the extent of reactive astrogliosis (RA) as observed through F-THK-5351 PET imaging in amyloid-negative patients who experienced their first stroke.
- - Researchers examined 63 patients about 3 months post-stroke, using various imaging and cognitive assessments to evaluate the relationship between RA (measured as Z-SUM scores) and cognitive function, adjusting for other health variables.
- - Results indicated that patients with PSCI were typically older, less educated, and exhibited greater brain atrophy. The analysis showed significant associations between Z-SUM scores and cognitive functions, suggesting that RA plays a role in the severity of
Article Abstract
Background: The aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized F-THK-5351 positron-emission tomography (PET) imaging in amyloid-negative patients with first-ever stroke.
Methods: We prospectively enrolled 63 amyloid-negative patients with first-ever stroke. Neurocognitive evaluation, MRI, F-THK-5351, and F-florbetapir PET were performed around 3 months after stroke. The F-THK-5351 uptake intensity was normalized using a signal distribution template to obtain the Z-SUM scores as the RA extent in the whole brain and cerebral hemisphere ipsilateral to stroke lesion. We evaluated stroke volume, leukoaraiosis, and brain atrophy on MRI. We used a comprehensive neurocognitive battery to obtain composite cognitive scores, and defined PSCI as a general cognitive function score < - 1. We analyzed the influence of Z-SUM scores on PSCI severity after adjusting for demographic, vascular, and neurodegenerative variables.
Results: Twenty-five of 63 stroke patients had PSCI. Patients with PSCI had older age, lower education, and more severe cortical atrophy and total Z-SUM scores. Total Z-SUM scores were significantly associated with general cognitive and executive functions at multiple regression models. Path analyses showed that stroke can exert cognitive influence directly by stroke itself as well as indirectly through RA, including total and ipsilateral Z-SUM scores, in patients with either right or left hemisphere stroke.
Conclusion: The patterns and intensity of F-THK-5351 uptake in amyloid-negative patients with first-ever stroke were associated with PSCI manifestations, which suggests that RA presents a modulating effect in PSCI development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568828 | PMC |
| http://dx.doi.org/10.1186/s12974-020-01985-0 | DOI Listing |
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