Arsenic (As) occurs naturally and concentrations in water bodies can reach high levels, leading to accumulation in vital organs like the spleen. Being an important organ in immune response and blood development processes, toxic effects of As on the spleen could compromise immunity and cause associated disorders in affected individuals. Splenic detoxification is key to improving the chances of survival but relatively little is known about the mechanisms involved. Essential trace elements like zinc have shown immune-modulatory effects humans and livestock. This study aimed to investigate the mechanisms involved in As-induced splenic toxicity in the common carp (Cyprinus carpio), and the protective effects of zinc (Zn). Our findings suggest that environmental exposure to As caused severe histological injuries and Ca accumulation in the spleen of common carp. Additionally, transcriptional and translational profiles of endoplasmic reticulum stress, apoptosis and autophagy-related genes of the spleen showed upward trends under As toxicity. Treatment with Zn appears to offer protection against As-induced splenic injury in common carp and the pathologic changes above were alleviated. Our results provide additional insight into the mechanism of As toxicity in common carp while elucidating the role of Zn, a natural immune-modulator, as a potential antidote against As poisoning.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ecoenv.2020.111473 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aging Oocytes: Exploring Apoptosis and Its Impact on Embryonic Development in Common Carp (Cyprinus carpio).
J Anim Sci
January 2025
Research Institute of Fish Culture and Hydrobiology, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodňany 389 01, Czech Republic.
Ovulation, fertilization, and embryo development are orchestrated and synchronized processes essential for the optimal health of offspring. Post-ovulatory aging disrupts this synchronization and impairs oocyte quality. In addition, oocyte aging causes fertilization loss and poor embryo development.
View Article and Find Full Text PDFImmunological memory in a teleost fish: common carp IgM B cells differentiate into memory and plasma cells.
Front Immunol
January 2025
Laboratory of Fish Protistology, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czechia.
From ancient cold-blooded fishes to mammals, all vertebrates are protected by adaptive immunity, and retain immunological memory. Although immunologists can demonstrate these phenomena in all fish, the responding cells remain elusive, without the tools to study them nor markers to define them. Fundamentally, we posited that it is longevity that defines a memory cell, like how it is antibody production that defines a plasma cell.
View Article and Find Full Text PDFPrior heatwave exposure improves hypoxia tolerance in a typical freshwater fish species.
Comp Biochem Physiol A Mol Integr Physiol
January 2025
Beijing Normal University, Beijing 100875, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Science, Beijing 100012, China.
The prevalence of heatwave and hypoxia events and their devastating impacts on aquatic ecosystems and fishery resources reinforces the priority of research to address the resilience and adaption mechanisms to these two stressors in important fish species. However, our understanding of the development of cross-tolerance of these two stressors in fish still limited. Here, we investigated the impacts of prior heatwave exposure on hypoxia tolerance and the underlying mechanisms in silver carp (Hypophthalmichthys molitrix), a species of considerable ecological and commercial importance.
View Article and Find Full Text PDFCorrection: The Concentration of Potentially Toxic Elements in Common Carp (Cyprinus carpio) Fish: Systematic Review and Meta-Analysis and Dietary Health Risk Assessment.
Biol Trace Elem Res
December 2024
Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Effects of (L.) fruit extract on the profile of hematology of ranchu goldfish ().
Open Vet J
November 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Article Synopsis
- The study investigates the effects of calabash fruit extract (BFE) on the growth and blood health of ranchu goldfish, showing that higher concentrations of BFE improve these aspects.
- Group P6, which received the highest BFE concentration, demonstrated the best growth performance and increased levels of specific immune cells (CD4+).
- The findings suggest that BFE could serve as an effective immunostimulant in fish diets, impacting both performance and hematological profiles positively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!