AI Article Synopsis
- - The review explores the relationship between neuronal plasticity and glioma growth, focusing on how various neurotransmitters, ion channels, and signaling pathways impact this interaction.
- - It examines how synaptic information is transferred to glioma cells and how these cancer cells utilize mechanisms from synaptic plasticity to promote their own growth.
- - Key findings highlight the roles of glutamate, calcium, potassium, chloride, and sodium channels, suggesting potential molecular targets for improving clinical treatments of brain tumors.
Article Abstract
There has been a significantly rising discussion on how neuronal plasticity communicates with the glioma growth and invasion. This literature review aims to determine which neurotransmitters, ion channels and signaling pathways are involved in this context, how information is transferred from synaptic sites to the glioma cells and how glioma cells apply established mechanics of synaptic plasticity for their own increment. This work is a compilation of some outstanding findings related to the influence of the glutamate, calcium, potassium, chloride and sodium channels and other important brain plasticity molecules over the glioma progression. These topics also include the relevant molecular signaling data which could prove to be helpful for an effective clinical management of brain tumors in the future.
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| http://dx.doi.org/10.1016/j.neuint.2020.104879 | DOI Listing |
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