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Three-dimensional genome architecture in intrahepatic cholangiocarcinoma.
Cell Oncol (Dordr)
January 2025
College of Life Science and Technology, Innovation Center of Molecular Diagnostics, Beijing University of Chemical Technology, Beijing, 100029, China.
Purpose: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%. Therefore, it is crucial to elucidate the molecular mechanisms of ICC. Recently, the advance of high-throughput chromosome conformation capture (Hi-C) technology help us look insight into the three-dimensional (3D) genome structure variation during tumorigenesis.
View Article and Find Full Text PDFGlucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms.
Adv Healthc Mater
January 2025
Department of Biochemistry and Molecular and Cellular Biology, School of Medicine, Georgetown University, Washington, DC, 20057, USA.
Glucocorticoids (GCs) are standard-of-care treatments for inflammatory and immune disorders, and their long-term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely understood. Herein, the study investigates the mechanisms of bone microvascular barrier function via osteoblast-endothelial interactions in response to GCs.
View Article and Find Full Text PDFUnraveling the structure-property relationships in fluorescent phenylhydrazones: the role of substituents and molecular interactions.
RSC Adv
January 2025
Institute of Polymer and Dye Technology, Lodz University of Technology Stefanowskiego 16 Lodz 90537 Poland.
This study investigates the structure-property relationships of a series of phenylhydrazones bearing various electron-donating and electron-withdrawing substituents, such as methoxy, dimethylamino, morpholinyl, hydroxyl, chloro, bromo, and nitro groups. The compounds were synthesized, and their structures were characterized using single-crystal X-ray diffraction, powder X-ray diffraction, FTIR spectroscopy, NMR spectroscopy, and DSC. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectroscopy and UV-Vis spectroscopy were employed to elucidate the complex interplay between the molecular skeleton, substituents, and the resulting photophysical properties.
View Article and Find Full Text PDFInteractive 3D visualisation technique used in pulmonary rehabilitation in chronic obstructive pulmonary disease: A randomised controlled study evaluating quality of life, compliance and use of health care.
Digit Health
January 2025
Medical Unit Occupational therapy and Physiotherapy, Women's Health and Allied Health Professionals Theme, Karolinska University Hospital, Stockholm, Sweden.
Introduction: A pulmonary rehabilitation (PR) programme, including exercise training, education, and behaviour change, is highly recommended in treatment guidelines for chronic obstructive pulmonary disease (COPD). A new PR educational material for PR using an interactive three-dimensional (3D) visualisation technique was developed. There is little known regarding using 3D in this setting.
View Article and Find Full Text PDFModeling long-range DNA dependencies is crucial for understanding genome structure and function across a wide range of biological contexts. However, effectively capturing these extensive dependencies, which may span millions of base pairs in tasks such as three-dimensional (3D) chromatin folding prediction, remains a significant challenge. Furthermore, a comprehensive benchmark suite for evaluating tasks that rely on long-range dependencies is notably absent.
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