AI Article Synopsis
- COVID-19 has led to a unique coagulopathy known as COVID-19-induced coagulopathy (CIC), characterized by high levels of D-dimer and fibrin split products, while traditional coagulation tests show minimal changes.
- CIC is distinct from sepsis-induced coagulopathy and involves a severe cytokine storm, resulting in significant blood clotting issues and organ damage.
- A proposed scoring system for CIC aims to guide anticoagulation therapy based on patient risk categories, with the understanding that guidelines will evolve as more research is conducted.
Article Abstract
COVID-19 has become a pandemic in the United States and worldwide. COVID-19-induced coagulopathy (CIC) is commonly encountered at presentation manifested by considerable elevation of D-dimer and fibrin split products but with modest or no change in activated partial thromboplastin time and prothrombin time. CIC is a complex process that is distinctly different from conventional sepsis-induced coagulopathy. The cytokine storm induced by COVID-19 infection appears to be more severe in COVID-19, resulting in development of extensive micro- and macrovascular thrombosis and organ failure. Unlike conventional sepsis, anticoagulation plays a key role in the treatment of COVID-19, however without practice guidelines tailored to these patients. We propose a scoring system for COVID-19-coagulopathy (CIC Scoring) and stratification of patients for the purpose of anticoagulation therapy based on risk categories. The proposed scoring system and therapeutic guidelines are likely to undergo revisions in the future as new data become available in this evolving field.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543932 | PMC |
| http://dx.doi.org/10.1016/j.blre.2020.100761 | DOI Listing |
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