AI Article Synopsis
- - Septic shock can occur from infections, leading to decreased blood flow due to blood vessel dilation; a patient with septic shock received methylene blue to stabilize his blood pressure but ultimately died.
- - An autopsy revealed a bluish-green discoloration in vital organs, particularly the heart, lungs, and brain, attributed to the administration of methylene blue rather than post-mortem changes or infection-related pigments.
- - The case highlights the need for further research to help pathologists differentiate between the effects of methylene blue treatment and other causes of organ pigmentation in septic cases.
Article Abstract
Septic shock can result from the dissemination of infections and can lead to hypoperfusion secondary to vasodilation. Methylene blue can help stabilize blood pressure refractory to other measures in shock. We report a case of a 58-year-old male who died of septic shock due to bacteremia secondary to acute folliculitis and epididymo-orchitis. He was given methylene blue for reversal of septic shock but he did not respond and expired. Autopsy findings were significant for bluish-green discoloration of organs, especially the heart, lungs, and brain during prosection secondary to methylene blue treatment. It is important to recognize artifacts of treatment and to discern them from changes due to putrefaction or the classic green pigmentation associated with infection, such as chloronychia. The case report illustrates that circulating methylene blue and its metabolites can accumulate in the organs in a dose-related fashion, imparting an interesting turquoise to dark blue-green pigment during the autopsy. Additional studies are warranted to enable pathologists to differentiate among the pigmentation associated with bacteremia, putrefaction, and methylene blue treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556683 | PMC |
| http://dx.doi.org/10.7759/cureus.10434 | DOI Listing |
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