Prognostic and Therapeutic Significance of Androgen Receptor in Patients with Gastric Cancer.

Purpose: The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions.

Patients And Methods: In this study, we have investigated the expression profile of and EMT-related genes in fresh gastric cancer (GC), adjacent nontumor and normal gastric tissues, as well as the effect and molecular mechanisms of inhibition in GC cell lines.

Results: Amongst 60 GC patients, 66.7% overexpressed that was remarkably correlated with the overexpression of . overexpression was also remarkably associated with unfavorable outcome (HR=3.478, =0.001); however, multivariate Cox regression analysis indicated that it was not an independent prognostic factor (HR=2.089, =0.056). This study has investigated simultaneous assessment of and EMT-related genes expression and indicated that concurrent overexpression of and is an independent unfavorable factor for GC overall survival after adjustment with other variables (HR=2.382, =0.021). Interestingly, the inhibition of signaling by potent antagonist enzalutamide suppressed cell growth, migration and invasion of GC cells via regulation of apoptosis-, cell cycle-, and EMT-related gene expressions.

Conclusion: Our findings have clinical importance proposing as an important prognostic factor involved in GC progression and metastasis, and submit inhibition as an appealing therapeutic approach for GC patients, either as a single agent or in a combined-modal strategy.