AI Article Synopsis
- Vitamin D has anti-inflammatory properties and may help improve outcomes in children with inflammatory bowel disease (IBD) and low vitamin D levels.
- A clinical trial with 120 children found that those receiving vitamin D supplementation showed significant improvements in IBD activity scores and quality of life compared to a placebo group.
- Inflammatory markers decreased, while levels of IL-10 increased, suggesting that vitamin D may enhance immune regulation and overall health in these patients.
Article Abstract
Background: Vitamin D has anti-inflammatory and immune regulatory functions.
Goals: The authors investigated the effect of vitamin D supplementation in children with inflammatory bowel disease (IBD) and hypovitaminosis D on disease activity, quality of life (QOL), inflammatory markers, and cytokines.
Study: This randomized double-blinded controlled clinical trial included 120 children with IBD and hypovitaminosis D; 22 of them were excluded later. Patients were randomized to receive either oral vitamin D3 in a dose of 2000 IU/day or placebo for 6 months. The primary outcome was to evaluate the effect of vitamin D supplementation on the IBD activity score. The secondary outcomes were to assess the QOL, inflammatory markers, cytokines, the safety of vitamin D, and to correlate serum vitamin D level with various clinical and laboratory variables.
Results: Vitamin D supplementation significantly decreased the IBD activity score in the vitamin D group compared with the placebo group. Moreover, QOL significantly improved after vitamin D supplementation. Inflammatory markers, for example, erythrocyte sedimentation rate, C-reactive protein, and fecal calprotectin and interleukin-2 IL-12, IL-17, IL-23, and tumor necrosis factor-alpha significantly decreased in the vitamin D group. However, IL-10 significantly increased after vitamin D supplementation. Vitamin D was significantly inversely correlated with the activity score, QOL score, levels of all inflammatory markers, the frequency of hospitalization, and emergency department visits.
Conclusion: Vitamin D supplementation may have a beneficial effect in children with IBD.
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| http://dx.doi.org/10.1097/MCG.0000000000001443 | DOI Listing |
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