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| http://dx.doi.org/10.3174/ajnr.A6826 | DOI Listing |
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Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice.
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Laboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs).
Methods: From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections of gadodiamide (2.5 mmol/kg, linear), gadobutrol (2.
Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage.
Front Cardiovasc Med
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National Key Laboratory for Innovation and Transformation of Luobing Theory, Jinan, China.
Background: Cardiac amyloidosis (CA) is a challenging diagnosis, particularly when the classic signs, such as increased wall thickness in a non-dilated left ventricle (LV), are absent. This makes the diagnosis more difficult in patients with normal LV wall thickness. We present a case of CA without increased wall thickness and without the characteristic granular sparkling echotexture in a non-dilated LV.
View Article and Find Full Text PDFElectrochemical Method for the Design of New Possible Gadolinium-Based Contrast Agents.
Nanomaterials (Basel)
December 2024
Laboratory of Applied Electrochemistry, Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi, 19, 20133 Milan, Italy.
Magnetic resonance imaging (MRI) is a technique that employs strong magnetic fields and radio frequencies to generate detailed images of the body's interior. In oncology patients, gadolinium-based contrast agents (GBCAs) are frequently administered to enhance the visualization of tumors. Those contrast agents are gadolinium chelates, characterized by high stability that prevents the release of the toxic gadolinium ion into the body.
View Article and Find Full Text PDFArticle Synopsis
- The Gadolinium Research and Education Committee (GREC) monitors and improves the safety and effectiveness of gadolinium-based contrast agents (GBCAs) used in MRI, emphasizing the need for alternatives and careful dosage.
- GBCAs are crucial for enhancing MRI images and clinical decision-making, and guidelines recommend their use only when necessary and at the lowest effective dose.
- The article discusses evaluating GBCA use in terms of cost-effectiveness, environmental impact, and the benefits of emerging next-generation GBCAs, which promise better stability and effectiveness at reduced doses.
Assessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by cardiovascular magnetic resonance quantitative stress perfusion.
J Cardiovasc Magn Reson
December 2024
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China; Clinical Research Center for Medical Imaging in Hunan Province, Changsha, China. Electronic address:
Background: Cardiac involvement in light chain amyloidosis (AL) is the main determinant of prognosis. Amyloid can be deposited in the extracellular space and cause an increase in extracellular volume fraction (ECV). At the same time, amyloid can also be deposited in the wall of small vessels and cause microvascular dysfunction.
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