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| http://dx.doi.org/10.1016/j.medin.2020.07.013 | DOI Listing |
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Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs: A Systematic Review.
JAMA Neurol
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Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Importance: Multiple continuous intravenous anesthetic drugs (CIVADs) are available for the treatment of refractory status epilepticus (RSE). There is a paucity of data comparing the different types of CIVADs used for RSE.
Objective: To systematically review and compare outcome measures associated with the initial CIVAD choice in RSE in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
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Department of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Unlabelled: Status epilepticus (SE) is a life-threatening condition associated with at least 5 min of continuous seizures or repeated seizures without regaining consciousness between episodes. It is a medical emergency with significant morbidity and mortality. The most common causes of SE are previous seizures, stroke, trauma, metabolic disorders, and central nervous system tumor.
View Article and Find Full Text PDFThiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation.
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Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation.
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Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China.
Chiral acetylenic derivatives are found in many bioactive compounds and are versatile functional groups in organic chemistry. Here, we describe an enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction from simple achiral materials under mild condition. The introduction of a Lewis acid cocatalyst is crucial to the efficiency of the transformation.
View Article and Find Full Text PDFThiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation.
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