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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849941 | PMC |
| http://dx.doi.org/10.1093/neuonc/noaa234 | DOI Listing |
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The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair.
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January 2025
State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Nucleotide availability is crucial for DNA replication and repair; however, the coordinating mechanisms in vivo remain unclear. Here, we show that the circadian clock in the liver controls the activity of the pentose phosphate pathway (PPP) to support de novo nucleotide biosynthesis for DNA synthesis demands. We demonstrate that disrupting the hepatic clock by genetic manipulation or mistimed feeding impairs PPP activity in male mice, leading to nucleotide imbalance.
View Article and Find Full Text PDFResveratrol and Extra Virgin Olive Oil: Protective Agents Against Age-Related Disease.
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Scientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya 39, 400087 Volgograd, Russia.
Resveratrol and extra virgin olive oil are both recognized for their potential protective effects against age-related diseases. This overview highlights their mechanisms of action, health benefits, and the scientific evidence supporting their roles in promoting longevity and cognitive health. A literature search was conducted.
View Article and Find Full Text PDFBackground: There is continuous demand for safe, effective cosmetic ingredients to treat the signs of aging skin, including fine lines, wrinkles, brown spots, discoloration, laxity, and sagging. While there are a plethora of cosmeceutical peptides, few combine anti-aging and anti-inflammatory benefits with small size.
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Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil.
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School of Pharmacy, School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococcus aureus and Propionibacterium acnes.
View Article and Find Full Text PDFCurcumin liposomes alleviate senescence of bone marrow mesenchymal stem cells by activating mitophagy.
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Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
The senescence of mesenchymal stem cells (MSCs) is closely related to aging and degenerative diseases. Curcumin exhibits antioxidant and anti-inflammatory effects and has been extensively used in anti-cancer and anti-aging applications. Studies have shown that curcumin can promote osteogenic differentiation, autophagy and proliferation of MSCs.
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