Background: There is usually a strong worry with feelings over the lost individual or body parts. Amputation sometimes leads to feelings of social discomfort or public self-consciousness. Social discomfort has been linked with further psychosocial problems such as increased activity restriction, heightened worry and low mood. Studies have associated limb loss care with psychological burden, financial burden, bodily and emotional stress on family and social relationship. The purpose of this research was to determine the psychosocial effects of amputation.
Method: A descriptive cross-sectional study involving 68 adult amputees using a structured interviewer-administered questionnaire adapted from Hospital Anxiety and Depression Scale which assessed psychological effects (anxiety and depression) and social impact scale which measured social effect of amputation on amputees. Fisher's exact test was used in the analysis to establish association using SPSS software version 23.
Result: Disease was the major cause of amputation 54.4% and below knee amputation was the most common site (44.1%). Majority of the participants, (86.7%) had caregivers out of which family and relatives constituted 91.5% and those with co-morbid medical conditions were 48.5% with diabetes mellitus being most prevalent in 60.6% of amputees with co-morbid medical conditions.Participants who were >50 years were twelve times less likely to have anxiety compared to those who were ≤ 50 years. There was statistically significant association between age of participants and anxiety. (OR = 0.081, p = 0.013, CI = 0.011- 0.594).
Conclusion: Majority of the participants had caregivers, out of which, family and relatives constituted significant proportion. About half of the participants had co-morbid medical conditions. Age was significantly associated with anxiety. This study revealed that having a care giver reduced depression, anxiety and social effect among amputees.
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Autism Res
January 2025
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with and without intellectual disability. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments in autistic individuals has not been described. We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024.
View Article and Find Full Text PDFEur J Clin Invest
January 2025
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
From 1999 to 2020, age-adjusted mortality rates (AAMR) for atrial fibrillation-related deaths among U.S. adults (age ≥25) with comorbid diabetes mellitus increased significantly with an annual percent change of 6.
View Article and Find Full Text PDFJ ECT
January 2025
From the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
Background: Electroconvulsive therapy (ECT) is an effective treatment for treatment-resistant depression (TRD). There are limited data on the improvement of anxiety symptoms in patients receiving ECT for TRD.
Objective: The aim of the study was to examine the extent to which anxiety symptom severity improves, relative to improvements in depressive symptoms, in TRD patients receiving an acute course of ECT.
Am J Obstet Gynecol
January 2025
Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Cleveland OH; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH. Electronic address:
Background: The use of glucagon-like-peptide-1 receptor agonists (GLP-1RAs) has greatly increased in patients of reproductive age within the past four years. However, there is minimal research into the long-term impact of these medications on future pregnancies.
Objectives: We aimed to evaluate the association between adverse obstetric outcomes and antecedent GLP-1RA use using a nationally representative database.
Aliment Pharmacol Ther
January 2025
Division of Gastroenterology, Hepatology, and Nutrition, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Background: Obesity has been linked to a more severe phenotype in patients with ulcerative colitis (UC).
Aim: To evaluate the impact of obesity on outcomes of advanced therapies in UC.
Methods: We conducted a retrospective cohort study utilising the TriNetX database comparing the composite score of corticosteroid use, change in advanced therapy or colectomy within two years between two cohorts of patients with UC-those with obesity (BMI ≥ 30 kg/m) and those without (BMI 18.
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