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Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits.
Vaccines (Basel)
December 2024
Drug Safety Research and Development, Pfizer Research & Development, Pearl River, NY 10965, USA.
: Respiratory syncytial virus (RSV) infections usually cause mild, cold-like symptoms in most people, but are a leading infectious disease causing infant death and hospitalization and can result in increased morbidity and mortality in older adults and at-risk individuals. Pfizer has developed Abrysvo, an unadjuvanted bivalent recombinant protein subunit vaccine containing prefusion-stabilized fusion (F) proteins representing RSV A and RSV B subgroups (RSVpreF). It is the only RSV vaccine approved for both maternal immunization to protect infants and active immunization of older adults (≥60 years) and 18-59-year-old individuals with high-risk conditions for prevention of RSV disease.
View Article and Find Full Text PDFExploring factors influencing childhood immunization status in East Africa using multilevel ordinal logistic regression analysis.
Front Public Health
January 2025
Department of Statistics, Bahir Dar University, Bahir Dar, Ethiopia.
Introduction: Childhood vaccinations are crucial in safeguarding children from infectious diseases and are recognized as one of the most cost-effective public health interventions. However, children in East African countries face more than a fifteen-fold increased risk of death from vaccine-preventable diseases compared to those in high-income nations. This study aimed to identify the factors influencing childhood immunization status in East Africa.
View Article and Find Full Text PDFApnea After 2-Month Vaccinations in Hospitalized Preterm Infants: A Randomized Clinical Trial.
JAMA Pediatr
January 2025
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.
Importance: Preterm infants are recommended to receive most vaccinations at the same postnatal age as term infants. Studies have inconsistently observed an increased risk for postvaccination apnea in preterm infants.
Objective: To compare the proportions of hospitalized preterm infants with apnea and other adverse events in the 48 hours after 2-month vaccinations vs after no vaccinations.
Maternal immunization impairs lymphoma growth and CNS/ocular metastasis in the offspring.
Front Immunol
January 2025
Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Maternal immunization is an important tool directed against a variety of infectious maladies in the offspring. A complementary, but less explored area is the use of maternal immunization in the prevention and treatment of childhood cancers. This in part stems from the lack of adequate experimental model systems.
View Article and Find Full Text PDFMaternal Knowledge and Practice during Postnatal Period Regarding Newborn Care at Hospital Setting.
Mymensingh Med J
January 2025
Dr Mst Shahana Afreen, Assistant Registrar, Department of Paediatrics, Rangpur Medical College Hospital, Rangpur, Bangladesh; E-mail:
Care of newborn is traditionally provided by mothers. Maternal knowledge and practice of newborn care can significantly affect neonatal morbidity and mortality. There is convincing concern to explore knowledge and practice of postnatal mothers regarding newborn care.
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