The pharmaceutical and manufacturing chemist John Lloyd Bullock, who had joined the Chemical Society in 1842 and who played a fundamental role in the creation of the Royal College of Chemistry in 1845, did not receive an obituary when he died in 1905. Yet, nine years later on the eve of WW1, the Council of the Chemical Society suddenly commissioned an obituary from two German chemists. Although the curious circumstances of this omission and commission cannot be fully explained, their investigation provides an opportunity for an appraisal of Bullock's role in the history of chemistry and pharmacy.
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http://dx.doi.org/10.1080/00026980.2020.1826822 | DOI Listing |
Nat Neurosci
September 2024
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary tract (NTS) in mice contains heterogenous neuronal populations that differentially control breathing. Within these subtypes, activation of tachykinin 1 (Tac1)-expressing neurons triggers specific respiratory behaviors that, as revealed by our detailed characterization, are cough-like behaviors.
View Article and Find Full Text PDFComput Methods Programs Biomed
June 2024
Department of ECE, University of British Columbia, Vancouver, V6T 1Z4, BC, Canada.
Statement Of Problem: Advanced cases of head and neck cancer involving the mandible often require surgical removal of diseased sections and subsequent replacement with donor bone. During the procedure, the surgeon must make decisions regarding which bones or tissues to resect. This requires balancing tradeoffs related to issues such as surgical access and post-operative function; however, the latter is often difficult to predict, especially given that long-term functionality also depends on the impact of post-operative rehabilitation programs.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
January 2024
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Throat tumour margin control remains difficult due to the tight, enclosed space of the oral and throat regions and the tissue deformation resulting from placement of retractors and scopes during surgery. Intraoperative imaging can help with better localization but is hindered by non-image-compatible surgical instruments, cost, and unavailability. We propose a novel method of using instrument tracking and FEM-multibody modelling to simulate soft tissue deformation in the intraoperative setting, without requiring intraoperative imaging, to improve surgical guidance accuracy.
View Article and Find Full Text PDFRev Sci Instrum
December 2023
Department of Physics, The University of Tokyo, Tokyo 113-0033, Japan.
Purpose: To characterize angle kappa and study the relationship between preoperative angle kappa and postoperative refractive accuracy, visual outcomes, and patient satisfaction in a large population of eyes with multifocal intraocular lens (MIOL) implantation.
Methods: A comprehensive electronic medical record chart review of 26,470 consecutive eyes that underwent immediate sequential bilateral cataract or refractive lens exchange with MIOLs was conducted. The primary outcome measures were postoperative monocular uncorrected distance visual acuity (UDVA), manifest refraction sphere and cylinder, spherical equivalent (SEQ), defocus equivalent (DEQ), subjective quality of vision at near, intermediate, and distance, and the likelihood of recommending the procedure.
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