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Optical coherence tomography outcomes from SPRINT-MS, a multicenter, randomized, double-blind trial of ibudilast in progressive multiple sclerosis. | LitMetric

AI Article Synopsis

Article Abstract

Background: The SPRINT-MS trial demonstrated benefit of ibudilast on brain atrophy over 96 weeks in progressive multiple sclerosis (MS). Optical coherence tomography (OCT) was performed in all trial participants.

Objective: Report the OCT results of the SPRINT-MS trial.

Methods: OCT was obtained at baseline and every 6 months using spectral domain OCT and analyzed by an OCT reading center. Change in each OCT outcome measure by treatment group was estimated using linear mixed models.

Results: Change in pRNFL thickness was +0.0424 uM/year (95% confidence interval (CI): -0.3091 to 0.3939) for ibudilast versus -0.2630 uM (95% CI: -0.5973 to 0.0714) for placebo ( = 244,  = 0.22). Macular volume change was -0.00503 mm/year (-0.02693 to 0.01688) with ibudilast versus -0.03659 mm/year (-0.05824 to -0.01494) for placebo in the Spectralis cohort ( = 61,  = 0.044). For the Cirrus cohort, macular volume change was -0.00040 mm/year (-0.02167, 0.020866) with ibudilast compared to -0.02083 mm/year (-0.04134 to -0.00033) for placebo ( = 183,  = 0.1734). Ganglion cell-inner plexiform layer thickness change, available from Cirrus, was -0.4893 uM/year (-0.9132, -0.0654) with ibudilast versus -0.9587 uM/year (-1.3677, -0.5498) with placebo ( = 183,  = 0.12).

Conclusion: Retinal thinning in MS may be attenuated by ibudilast. Sample size estimates suggest OCT can be a viable outcome measure in progressive MS trials if a therapy has a large treatment effect.

Trial Registration: NN102/SPRINT-MS ClinicalTrials.gov number, NCT01982942.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046841PMC
http://dx.doi.org/10.1177/1352458520964409DOI Listing

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