AI Article Synopsis
- COVID-19 has impacted over 22 million patients globally as of August 2020, prompting the medical community to explore its underlying pathophysiology.
- One popular theory claims that SARS-CoV-2 proteins interact with hemoglobin, disrupting its function and causing iron accumulation.
- However, a study comparing critically ill COVID-19 patients to ARDS controls showed no evidence supporting this theory, as the hemoglobin-oxygen dissociation curve in COVID-19 patients aligned closely with the expected curve.
Article Abstract
SARS-CoV-2 disease (COVID-19) has affected over 22 million patients worldwide as of August 2020. As the medical community seeks better understanding of the underlying pathophysiology of COVID-19, several theories have been proposed. One widely shared theory suggests that SARS-CoV-2 proteins directly interact with human hemoglobin (Hb) and facilitate removal of iron from the heme prosthetic group, leading to the loss of functional hemoglobin and accumulation of iron. Herein, we refute this theory. We compared clinical data from 21 critically ill COVID-19 patients to 21 non-COVID-19 ARDS patient controls, generating hemoglobin-oxygen dissociation curves from venous blood gases. This curve generated from the COVID-19 cohort matched the idealized oxygen-hemoglobin dissociation curve well (Pearson correlation, R2 = 0.97, P.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716349 | PMC |
| http://dx.doi.org/10.3324/haematol.2020.264267 | DOI Listing |
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