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Targeted Amino Acid Substitutions in a Peptaibol Confer Activity against Fungal Plant Pathogens and Protect Host Tissues from Infection. | LitMetric

AI Article Synopsis

Article Abstract

Fungal species belonging to the genus are commonly used as biocontrol agents against several crop pathogens. Among their secondary metabolites, peptaibols are helical, antimicrobial peptides, which are structurally stable even under extreme pH and temperature conditions. The promise of peptaibols as agrochemicals is, however, hampered by poor water solubility, which inhibits efficient delivery for practical use in crop protection. Using a versatile synthetic strategy, based on green chemistry procedures, we produced water-soluble analogs of the short-length peptaibol trichogin. Although natural trichogin was inactive against the tested fungal plant pathogens (, , , and ), three analogs completely inhibited fungal growth at low micromolar concentrations. The most effective peptides significantly reduced disease symptoms by on common bean and grapevine leaves and ripe grape berries without visible phytotoxic effects. An in-depth conformational analysis featuring a 3D-structure-activity relationship study indicated that the relative spatial position of cationic residues is crucial for increasing peptide fungicidal activity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589190PMC
http://dx.doi.org/10.3390/ijms21207521DOI Listing

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