AI Article Synopsis
- People with Parkinson's disease (PwP) face a higher risk of malnutrition due to various factors, including both motor and non-motor symptoms, as well as complications from treatment.
- A study involving 87 PwP analyzed their nutritional status using various assessments, revealing that 34.4% were at risk of malnutrition while 8% were actually malnourished.
- The severity of motor symptoms (measured by the MDS-UPDRS Part III) was found to be the primary factor linked to poor nutritional status, while non-motor symptoms and treatment complications showed no significant association.
Article Abstract
Background: People with Parkinson's disease (PwP) are at higher risk of developing malnutrition. Several factors have been suggested to be involved including motor symptoms, non-motor symptoms, and treatment-related complications.
Objective: The objective of the study was to analyze the combined effect of motor, non-motor, and pharmacological factors in the risk of malnutrition in PwP.
Methods: Eighty-seven consecutive PwP were included in the study. Clinical data and pharmacological treatment were collected. Nutritional status was assessed using the Mini-Nutritional Assessment (MNA) questionnaire. Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Non-motor Symptoms Scale (NMSS), Hamilton Depression Rating Scale HAM-D, and Montreal Cognitive Assessment were applied.
Results: Thirty (34.4%) PwP were at risk of malnutrition and seven had malnutrition (8%). Abnormal nutritional status was associated with lower education, higher MDSUPDRS Parts I, II, and III and total scores, and higher scores in the NMSS domain of sleep disorders and fatigue. MDS-UPDRS motor score remained as a determinant of abnormal nutritional status, defined as MNA < 23.5, with an odds ratio 1.1 (95% confidence interval 1.01-1.10, p = 0.02).
Conclusion: The main factor associated with nutritional status was severity of the motor symptoms as assessed by the MDS-UPDRS Part III. Non-motor symptoms and treatment-related complications were not associated with malnutrition.
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| http://dx.doi.org/10.24875/RIC.20000010 | DOI Listing |
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