Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864237 | PMC |
| http://dx.doi.org/10.1152/physiol.00015.2020 | DOI Listing |
Publication Analysis
Top Keywords
opioids depress
8
prebötzinger complex
8
multi-level regulation
4
regulation opioid-induced
4
opioid-induced respiratory
4
respiratory depression
4
depression opioids
4
depress minute
4
minute ventilation
4
ventilation reducing
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!