Hydroxylated Ethacrylic and Tiglic Acid Derivatives from the Stems and Branches of and Their Potential Anti-inflammatory Activities.

J Nat Prod

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.

Published: October 2020

Two new hydroxylated ethacrylic acid derivatives (compounds and ) and 11 new hydroxylated tiglic acid derivatives (compounds -), together with one known compound (compound ), were isolated from the stems and branches of . Their structures were established by extensive spectroscopic analyses, while their absolute configurations were determined by X-ray crystallographic methods (compounds and ), Mo(OAc)-induced electronic circular dichroism experiments (compounds and ), and chemical methods (compounds -). This study is the first investigation on the secondary metabolites of this species. The anti-inflammatory activities of all isolated compounds were evaluated in an LPS-induced mouse peritoneal macrophage model. Notably, compounds and both exerted potent inhibitory effects on NO production with IC values of 2.9 and 1.2 μM, respectively.

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http://dx.doi.org/10.1021/acs.jnatprod.0c00286DOI Listing

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