A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes.

Trends Mol Med

Department of Pediatrics, Division of Infectious Diseases, Washington University in St. Louis School of Medicine, St Louis, MO, USA. Electronic address:

Published: December 2020

An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524648PMC
http://dx.doi.org/10.1016/j.molmed.2020.09.012DOI Listing

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