In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was used to help resolve the genetic determinants of ammonia-induced acute lung injury. The encoded proteins were prioritized based on molecular function, nonsynonymous SNP within a functional domain or SNP within the promoter region that altered expression. This integrative functional approach revealed 14 candidate genes that included , , , and , which had significant SNP associations, and , , , , , , and , which had suggestive SNP associations. Of these genes, , , , , and are particularly noteworthy and had pathophysiological roles that could be associated with acute lung injury in several ways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847062 | PMC |
| http://dx.doi.org/10.1152/ajplung.00276.2020 | DOI Listing |
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