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Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles. | LitMetric

AI Article Synopsis

  • A new, efficient method is introduced to load fluorescein isothiocyanate (FITC)-dextran onto the tips of DNA microneedles for drug delivery.
  • The technique combines a dispensing and suction method, optimizing the vacuum process to enhance the diffusion of FITC during microneedle manufacturing.
  • A micro-jetting system was developed for precise and fast loading, making this approach simpler and more effective than current methods, with potential clinical applications for drug delivery.

Article Abstract

Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process. In addition, the simulations were consistent with the experimental results and showed apparent diffusion. Moreover, dextrans of different molecular weights labeled with FITC were chosen to fabricate the tip of microneedles for demonstrating their applicability. Finally, a micro-jetting system with a micro-nozzle (diameter: 80 μm) was developed to achieve the accurate and rapid loading of small amounts of FITC using the anti-diffusion and micro-jetting methods. Our method not only uses a simple and fast manufacturing process, but also fabricates the tips of microneedles more efficiently with FITC compared with the existing methods. We believe that the proposed method is essential for the clinical applications of the microneedle drug delivery platform.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599544PMC
http://dx.doi.org/10.3390/pharmaceutics12100954DOI Listing

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