This paper focuses on the fire risk assessment for commercial complex, as the variety of fire accidental triggers inside could be a big threat to the public fire safety, leading to catastrophic loss in human lives and properties. Both the qualitative and quantitative analysis were imposed on a typical large commercial complex to recognize the potential fire-causative factors in this paper. Applying the fault tree analysis, the basic events leading to fire are acquired, and they are then further reclassified based on the analytic hierarchy process. Taking the damage of the accident as the target layer and the fire-causative factors, the equipment operation factors and firefighting factors as the criterion layer, the assessment index is well established. The risk of each factor is quantitatively evaluated, and the effect of each factor on the target layer is analyzed. The result of the fault tree analysis and analytic hierarchy process shows good consistency, in which human behavior is the main factor leading to the fire occurrence, followed by the combustible material, the rescue speed and the staff assignment factors. The results are beneficial for general decisions and measures in public fire safety management.
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http://dx.doi.org/10.3390/ijerph17197347 | DOI Listing |
STAR Protoc
January 2025
Gladstone Institutes, San Francisco, CA, USA; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA, USA; Department of Pediatrics, Cardiovascular Research Institute, Institute for Human Genetics, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:
As light sheet fluorescence microscopy (LSFM) becomes widely available, reconstruction of time-lapse imaging will further our understanding of complex biological processes at cellular resolution. Here, we present a comprehensive workflow for in toto capture, processing, and analysis of multi-view LSFM experiments using the ex vivo mouse embryo as a model system of development. Our protocol describes imaging on a commercial LSFM instrument followed by computational analysis in discrete segments, using open-source software.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A Raja SC Mullick Road, Kolkata, West Bengal 700032, India.
Designing catalysts for the selective reduction of CO, resulting in products having commercial value, is an important area of contemporary research. Several molecular catalysts have been reported to facilitate the reduction of CO (both electrochemical and photochemical) to yield 2e/2H electron-reduced products, CO and HCOOH, and selective reduction of CO beyond 2e/2H is rare. This is partly because the factors that control the selectivity of CO reduction beyond 2e are not yet understood.
View Article and Find Full Text PDFNat Chem
January 2025
Department of Bio-Organic Chemistry, Institute of Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
The cytoskeleton is a crucial determinant of mammalian cell structure and function, providing mechanical resilience, supporting the cell membrane and orchestrating essential processes such as cell division and motility. Because of its fundamental role in living cells, developing a reconstituted or artificial cytoskeleton is of major interest. Here we present an approach to construct an artificial cytoskeleton that imparts mechanical support and regulates membrane dynamics.
View Article and Find Full Text PDFSci Rep
January 2025
Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Spermatogenesis is one of the most complex processes of cell differentiation and its failure is a major cause of male infertility. Therefore, a proper model that recapitulates spermatogenesis in vitro has been long sought out for basic and clinical research. Testis organ culture using the gas-liquid interphase method has been shown to support spermatogenesis in mice and rats.
View Article and Find Full Text PDFNPJ Parkinsons Dis
January 2025
Department of Biostatistics, School of Public Health, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China.
The relationship between hearing loss (HL) and Parkinson's disease (PD) remains unclear. Using individual-level and summary-level data from the UK Biobank and the largest genome-wide association studies, we examined this link through observational, Mendelian randomization and genetic pleiotropy analyses. Among 158,229 participants, PD risk rose with HL severity especially in elder and males, and hearing aids significantly reduced PD risk in males.
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