AI Article Synopsis
- - The study used magnetisation transfer (MT) MRI to assess myelination in the gray and white matter of the brains of 78 healthy adults, finding that global myelination peaks around ages 42.9 for gray matter and 41.7 for white matter.
- - Researchers also examined the Nuclear Overhauser Enhancement (NOE) effect as a potential myelination measure, discovering a strong correlation between MT and NOE signals, with NOE showing similar although weaker age-related trends.
- - Additionally, they analyzed cortical thickness and confirmed a consistent linear decline of 4.5 ± 1.2 μm per year as age increases.
Article Abstract
We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19-62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 ± 1.2 μm/y.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2020.08.009 | DOI Listing |
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