Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer.

Cancer Cell

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address:

Published: October 2020

Cellular plasticity contributes to intratumoral heterogeneity, metastatic spread, and treatment resistance of cancers. In this issue of Cancer Cell, Gabitova-Cornell et al. identify the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer with agents commonly prescribed to manage heart disease risk.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976615PMC
http://dx.doi.org/10.1016/j.ccell.2020.09.010DOI Listing

Publication Analysis

Top Keywords

pancreas cancer
8
cholesterol biosynthesis
4
biosynthesis influences
4
influences subtype
4
subtype specificity
4
specificity plasticity
4
plasticity pancreas
4
cancer cellular
4
cellular plasticity
4
plasticity contributes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!