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Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. | LitMetric

Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes.

Neuron

Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065, USA; Kavli Neural Systems Institute, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

Published: December 2020

AI Article Synopsis

  • Blood-feeding mosquitoes, like Aedes aegypti, rely on nectar for energy but need blood meals for egg development, making accurate meal discrimination crucial.
  • Researchers studied the mosquitoes' stylet, a specialized appendage for blood-feeding, and discovered that certain neurons in the stylet specifically respond to different components of blood.
  • The ability of these neurons to differentiate between blood and nectar at the sensory level plays a significant role in the transmission of vector-borne diseases to humans.

Article Abstract

Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, and metabolic fates. We investigated the syringe-like blood-feeding appendage, the stylet, and discovered that sexually dimorphic stylet neurons taste blood. Using pan-neuronal calcium imaging, we found that blood is detected by four functionally distinct stylet neuron classes, each tuned to specific blood components associated with diverse taste qualities. Stylet neurons are insensitive to nectar-specific sugars and respond to glucose only in the presence of additional blood components. The distinction between blood and nectar is therefore encoded in specialized neurons at the very first level of sensory detection in mosquitoes. This innate ability to recognize blood is the basis of vector-borne disease transmission to millions of people worldwide.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831381PMC
http://dx.doi.org/10.1016/j.neuron.2020.09.019DOI Listing

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