Newly developed hip geometry parameters are associated with hip fracture.

Background: The conventional and newly developed geometry parameters at the femoral neck have formed a large geometry profile and their relationship with hip fracture was largely unknown. We aimed to evaluate the relationship between the geometry profile and hip fracture in Chinese.

Methods: The hip geometry profile contains seven conventional geometry parameters at femoral neck (FN) and thirty newly developed parameters at three sub-regions (Narrow Neck, NN; Intertrochanter, IT; Femoral shaft, FS) of the total hip. Based on 6294 recruited Chinese (≥65 years), 97 subjects with osteoporotic fracture (OF) history and 388 matched controls were selected. The t test, Chi-square statistic, conditional logistic regression model were used.

Results: Three geometric parameters (endocortical diameter, ED; cortical thickness, CT; buckling ratio, BR) have consistent differences at all the sites between the cases and controls (p < 0.01). Conventional geometry parameters (e.g., cross-sectional area, CSA; BR) and the newly developed parameters (e.g., NN_ED, NN_Outer Diameter, IT_ED) were identified as the risk factors of hip fracture independent of BMD. The additional predictive ability of the hip geometric parameters, over BMD alone, (receiver operating characteristic curve (ROC) analysis) was improved. Especially at NN, the area of ROC used single NN_BMD is only 0.596, but increased rapidly at 0.705 when combined with the hip geometric parameters.

Conclusions: This study found that three newly developed hip geometry parameters are associated with hip fracture. The results will increase our understanding of the determinants of fracture and provide potential clue for future prevention of fracture in Chinese Population.