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Article Abstract
Background: A meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer.
Methods: We systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI).
Results: Seven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58-2.12; AG vs. GG: OR=1.21, 95% CI=1.10-1.34; Dominant model: OR=1.33, 95% CI=1.22-1.46; Recessive model: OR=1.66, 95% CI=1.44-1.90). Moreover, this polymorphism was found to be correlated with the susceptibility to lung cancer when studies were stratified based on the sample size and the Hardy-Weinberg equilibrium.
Conclusion: The present findings indicate that the rs2736098 polymorphism may be a risk factor for the development of lung cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555572 | PMC |
| http://dx.doi.org/10.1177/0300060520936173 | DOI Listing |
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