AI Article Synopsis
- A new reaction has been developed that uses a bifunctional thiourea catalyst to enable an asymmetric tandem reaction involving benzylidene succinimides and β-trifluoromethyl enones.
- The process yields a variety of FC-containing chiral products with good to exceptional yields, achieving up to 98% yield and over 99% enantioselectivity.
- This study marks the first instance of utilizing benzylidene succinimides in this type of catalytic enantioselective transformation.
Article Abstract
A bifunctional thiourea-catalyzed asymmetric tandem α-functionalization/1,3-proton shift reaction of benzylidene succinimides with β-trifluoromethyl enones has been developed. A series of FC-containing chiral Rauhut-Currier type products were obtained in moderate to high yields (up to 98%) with excellent enantioselectivities (up to >99% ee). This represents the first example of benzylidene succinimides undergoing tandem α-functionalization/1,3-proton shift in catalytic enantioselective transformation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d0cc05474g | DOI Listing |
Publication Analysis
Top Keywords
tandem α-functionalization/13-proton
12
α-functionalization/13-proton shift
12
benzylidene succinimides
12
asymmetric tandem
8
shift reaction
8
reaction benzylidene
8
succinimides β-trifluoromethyl
8
β-trifluoromethyl enones
8
organocatalytic asymmetric
4
enones bifunctional
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!