Pyridine- and Thiazole-Based Hydrazides with Promising Anti-inflammatory and Antimicrobial Activities along with Their Studies.

A new class of compounds formed by the linkage of -C(O)-NH- with pyridine and thiazole moieties was designed, synthesized, and characterized by various spectral approaches. The newly characterized compounds were evaluated for their antimicrobial as well as anti-inflammatory properties. The anti-inflammatory activity of these compounds was evaluated by denaturation of the bovine serum albumin method and showed inhibition in the range of IC values-46.29-100.60 μg/mL. Among all the tested compounds, compound has the highest IC value and compound has the least IC value. On the other hand, antimicrobial results revealed that compound showed the lowest MIC values and compound has the highest MIC values. Furthermore, molecular docking of the active compounds demonstrated a better docking score and interacted well with the target protein. Physicochemical parameters of the titled compounds were found suitable in the reference range only. The molecular docking study revealed their COX-inhibitory action. Compound emerged as a significant bioactive molecule among the synthesized analogues.