Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus , and a human hepatoblastoma (HepDES19) revealed complementary biological profiles and new lead compounds with sub-micromolar activity against each pathogen.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543996 | PMC |
| http://dx.doi.org/10.1039/c9ra06383h | DOI Listing |
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