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| http://dx.doi.org/10.3389/fpsyg.2020.02173 | DOI Listing |
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Clinical Manifestations.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Individuals with preclinical Alzheimer's disease (AD) show reduced practice effects on annually repeated neuropsychological testing, suggesting a decreased ability to learn over repeated exposures. Remote, digital testing enables the assessment of learning over more frequent time intervals, thereby facilitating a more rapid detection of those early learning deficits. We previously showed that multi-day learning on the Boston Remote Assessment for Neurocognitive Health (BRANCH) was indeed diminished in Αβ+ cognitively unimpaired (CU) older adults.
View Article and Find Full Text PDFEarly midlife ovarian removal is associated with lower posterior hippocampal function.
Alzheimers Dement
December 2024
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.
Associating faces with names and meals as a biomarker of early AD in cognitively healthy individuals.
J Alzheimers Dis
December 2024
Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
The Learning and Associative Memory (LAM) test is a face-name associative memory test created to detect early Alzheimer's disease (AD). In a recent study, it was administered to cognitively healthy individuals with different levels of amyloid-β (Aβ) and tau burden. The key findings for LAM were: 1) selective correlations with Aβ levels, 2) unique discriminatory power between A + and A- individuals, 3) significantly higher areas under the curve in receiver operating curve analysis.
View Article and Find Full Text PDFObjective: Subjective cognitive decline (SCD) is defined as a self-reported perception of cognitive decline that occurs without clear objective signs of cognitive impairment. There is still uncertainty in the literature about the reliability of SCD as an accurate indicator of the early stages of major neurocognitive disorders. Furthermore, objectifying cognitive impairment in SCD is difficult, mainly due to the insensitivity of the assessment instruments.
View Article and Find Full Text PDFAssociations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.
Brain
October 2024
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK.
Article Synopsis
- Accelerated long-term forgetting (ALF) describes a situation where information is remembered well in the short term but forgotten quickly over longer periods, and it could be an early sign of cognitive decline, possibly related to Alzheimer's disease.
- In a study involving 429 participants aged about 73, researchers assessed ALF using visual and verbal memory tests and looked at the impact of brain pathology on memory retention and forgetting.
- Results showed that people with amyloid plaques (linked to Alzheimer's) forgot details of a complex figure more quickly than those without, and overall retention was higher for the 'outline' of the figure compared to 'detail' items.
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