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ReIU: an efficient preliminary framework for Alzheimer patients based on multi-model data.
Front Public Health
January 2025
Engineering Research Center of Photoelectric Detection and Perception Technology, Yunnan Normal University, Kunming, China.
The rising incidence of Alzheimer's disease (AD) poses significant challenges to traditional diagnostic methods, which primarily rely on neuropsychological assessments and brain MRIs. The advent of deep learning in medical diagnosis opens new possibilities for early AD detection. In this study, we introduce retinal vessel segmentation methods based on U-Net ad iterative registration Learning (ReIU), which extract retinal vessel maps from OCT angiography (OCT-A) facilities.
View Article and Find Full Text PDFAbstracts from the 2024 European Association for Vision and Eye Research Congress, 3-5 November 2024, Valencia.
Acta Ophthalmol
January 2025
Harvard University, Boston, Cambridge, USA.
Purpose: There is evidence of the role of dark adaptation (DA) as a functional biomarker in age-related macular degeneration (AMD) where foveal cones are impacted during the initial stages of AMD. In this study we determine the repeatability of smartphone application (MOBILE DA) to evaluate the cone-mediated dark adaptation (DA) in healthy young adults.
Methods: Testing was done by placing a smartphone in front of the subject in a dark room.
A comprehensive review of structure-function correlations in age-related macular degeneration: Contributions of microperimetry.
Surv Ophthalmol
January 2025
Department of Ophthalmology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Victor Babeș 8, 400012, Cluj-Napoca, Romania; Ophthalmology Clinic, Emergency County Hospital, Clinicilor 3-5, 400006, Cluj-Napoca, Romania. Electronic address:
Age-related macular degeneration (AMD) is a leading cause of visual impairment and irreversible blindness worldwide. High-resolution imaging techniques have been pivotal in characterizing the morphological alterations in the retina and in identifying structural biomarkers with prognostic significance. In clinical practice, visual function is primarily assessed through visual acuity testing, which, however, does not completely reflect the functional deficits experienced by patients.
View Article and Find Full Text PDFTorsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy.
PLoS One
January 2025
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States of America.
Traumatic optic neuropathy (TON) is a common cause of irreversible blindness following head injury. TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone.
View Article and Find Full Text PDFBacillary layer detachment: Updates on its clinical and prognostic significance in retinal disease.
Surv Ophthalmol
January 2025
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele-Milan, Italy; Department of Ophthalmology, Eye Unit Humanitas Gavazzeni-Castelli, via Mazzini 11, Bergamo, Italy.
Bacillary layer detachment (BALAD) refers to the distinctive splitting at the level of the photoreceptor inner segment myoid and accumulation of intraretinal fluid, as seen on optical coherence tomography (OCT).BALAD is an increasingly recognized OCT biomarker of numerous heterogeneous chorioretinal diseases, including posterior uveitis, age-related macular degeneration and macular neovascularization, neoplastic and paraneoplastic retinal disorders, rhegmatogenous retinal detachment, blunt ocular trauma, and miscellaneous conditions. The recognition of BALAD is clinically relevant because, based on the specific etiology, BALAD may require simple observation, ocular or systemic medical treatment, or even surgical intervention, with subsequent different prognosis.
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