Atmospheric dispersion calculation of radiological releases can be done for different purposes such as deterministic or probabilistic safety analysis, environmental impact assessment, emergency preparedness and response. The characteristics of the weather conditions used in such assessments have a significant effect on the results, thus it is vital to select appropriate meteorological data for the calculation. In this paper, we conduct a study on deterministic safety analysis of radiological releases and investigate the effects of using different subsets of a meteorological database for such assessments. We demonstrate that conducting deterministic dose assessment with a large site specific dataset of meteorological measurements and the use of a dose percentile is more beneficial than using one set of meteorological parameters. This is because variations in the meteorological condition have considerable effect on the dose results when using one set of meteorological parameters (e.g. worst case scenario) and less when a large meteorological database is used. We show that there can be a significant difference in the maximum dose computed with a large (at least annual with hourly resolution) meteorological database when there is a lack of data points or conversion of the parameters is needed, thus the 100th dose percentile is not optimal for verification of safety criteria fulfillment. It is better to use a relatively high percentile (e.g. from 80th to 99th), partly because it behaves more robustly and also because the use of the maximum dose (100th percentile) would be overly conservative. In case of meteorological data not being available for a sufficient temporal domain (e.g. data available for only one year or less), a multiplication factor - determined based on conservative assumptions and extensive studies on the possible spread of meteorological conditions and their effect at a given location - can be used for the comparison of a selected dose percentile with the safety limit. A 5-years long meteorological database provided by a meteorological measurement system was used in this study as an example to demonstrate and calibrate the methodology on a real database. The methods presented in this work are universal, they can be used in deterministic safety analysis of other nuclear facilities, and the results can facilitate the development of optimal meteorological databases.
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http://dx.doi.org/10.1016/j.jenvrad.2020.106428 | DOI Listing |
AAPS J
January 2025
Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, California, USA.
Protein-based therapeutics may elicit undesired immune responses in a subset of patients, leading to the production of anti-drug antibodies (ADA). In some cases, ADAs have been reported to affect the pharmacokinetics, efficacy and/or safety of the drug. Accurate prediction of the ADA response can help drug developers identify the immunogenicity risk of the drug candidates, thereby allowing them to make the necessary modifications to mitigate the immunogenicity.
View Article and Find Full Text PDFJ Cancer Educ
January 2025
Department of Pharmacy, Al Rafidain University College, 10001, Baghdad, Iraq.
Chemotherapy-drug interactions (CDIs) pose significant challenges in oncology, affecting treatment efficacy and patient safety. Despite their importance, there is a lack of validated tools to assess oncologists' knowledge of CDIs. This study aimed to develop and validate a comprehensive questionnaire to address this gap and ensure the reliability and validity of the instrument.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
January 2025
College of Food Science and Technology, Henan Agricultural University, Zhengzhou, 450002, People's Republic of China.
With the in-depth and comprehensive research on probiotic Bacillus, it has become a hot topic in food science. However, the current status of research using bibliometric analysis to assess the application of probiotic Bacillus in food science has not been comprehensively reviewed. The Web of Science (WOS) database was used in this review's bibliometric analysis to determine the hotspots for research as well as the extent of completed experiments.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
The optimal therapeutic intervention for pediatrics with optic pathway glioma (OPG) remained controversial in the literature. Recently, due to substantial adverse events (AEs) of chemotherapy and its impact on children's lives, the efficacy of other options has been investigated. Bevacizumab (BVZ) is an anti-vascular endothelial growth factor (VEGF) agent that alters the lesion microenvironment.
View Article and Find Full Text PDFEur J Clin Pharmacol
January 2025
Department of the Acute Pain Service, St. Luke's University Health Network, 801 Ostrum St, Bethlehem, PA, 18015, USA.
Purpose: Opioid medications remain a common treatment for acute pain in hospitalized patients. This study aims to identify factors contributing to opioid overdose in the inpatient population, addressing the gap in data on which patients are at higher risk for opioid-related adverse events in the hospital setting.
Methods: A retrospective chart review of inpatients receiving at least one opioid medication was performed at a large academic medical center from January 1, 2022, through December 31, 2022.
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