AI Article Synopsis
- A recent study highlighted how new metal-dithiocarbamato complexes show anti-cancer properties and could be potential drugs.
- The best compounds were placed in modified micellar nanocarriers, specifically Pluronic® F127, to promote targeted delivery to cancer cells.
- The micelles were tested for size, stability, and their ability to kill aggressive human cancer cells, with results confirmed through advanced microscopy and analysis techniques.
Article Abstract
A recent study on our metal-dithiocarbamato complexes pointed out the antiproliferative properties and the druglikeness of some new patented derivatives. In this work, the best compounds have been encapsulated in micellar nanocarriers, being also carbohydrate-functionalized on their hydrophilic surface to investigate the possibility of a cancer-selective delivery. In particular, the nonionic block copolymer Pluronic® F127 (PF127) has been chemically modified with sugars and the derivatives characterized by means of NMR spectroscopy and FT-IR spectrophotometry. Then, the two selected complexes (β-[Ru(PipeDTC)]Cl (PipeDTC = piperidine dithiocarbamate) and [Cu(ProOMeDTC)] (ProOMeDTC = L-proline methyl ester dithiocarbamate)), have been loaded into the hydrophobic core of PF127 micelles and cancer-targeting counterparts. These nanoformulations have been studied for their dimensions (DLS, TEM) and stability, and tested for their cytotoxicity against aggressive human cancer cell lines. The in vitro results were paralleled with mechanistic studies through Confocal Laser Scanning Microscopy and xCELLigence analysis.
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| http://dx.doi.org/10.1016/j.jinorgbio.2020.111259 | DOI Listing |
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