Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.injury.2020.10.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Twin Scholarships of Glycomedicine and Precision Medicine in Times of Single-Cell Multiomics.
OMICS
July 2024
School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions.
View Article and Find Full Text PDFSEEING IS NOT UNDERSTANDING: Vygotsky, Halliday and Metaphor in Forming and Forgetting Middle School Science Concepts.
Integr Psychol Behav Sci
September 2024
Teachers' College, Sangmyung University, Seoul, South Korea.
When teachers explain science concepts-for example, the solar wind, or plasma waves-some methods seem to be quick-acting and others long-lasting. Still others pose as many problems as they seem to solve. How, for example, does a parent explain how there can be solar wind without any air in space? How does a teacher explain how there can be plasma waves without any water? Locating metaphor between thinking and speech rather than within one or the other, we work out a single scheme to analyze two conversations with adult Koreans.
View Article and Find Full Text PDFLTP induction by structural rather than enzymatic functions of CaMKII.
Nature
September 2023
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades is that LTP induction requires enzymatic activity of the Ca/calmodulin-dependent protein kinase II (CaMKII). However, as we delineate here, the experimental evidence is surprisingly far from conclusive. All previous interventions inhibiting enzymatic CaMKII activity and LTP also interfere with structural CaMKII roles, in particular binding to the NMDA-type glutamate receptor subunit GluN2B.
View Article and Find Full Text PDFRegulation of translation by ribosomal RNA pseudouridylation.
Sci Adv
August 2023
Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.
Pseudouridine is enriched in ribosomal, spliceosomal, transfer, and messenger RNA and thus integral to the central dogma. The chemical basis for how pseudouridine affects the molecular apparatus such as ribosome, however, remains elusive owing to the lack of structures without this natural modification. Here, we studied the translation of a hypopseudouridylated ribosome initiated by the internal ribosome entry site (IRES) elements.
View Article and Find Full Text PDFNuclear mRNPs are compact particles packaged with a network of proteins promoting RNA-RNA interactions.
Genes Dev
June 2023
Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried/Munich D-82152, Germany;
Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; rather, they associate with mRNA-binding proteins to form messenger ribonucleoprotein (mRNP) complexes. Recently, global proteomic and transcriptomic studies have provided comprehensive inventories of mRNP components.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!