Bacterial biofilm contributes to antibiotic resistance. Developing antibiofilm agents, more favored from natural origin, is a potential method for treatment of highly virulent multidrug resistant (MDR) bacterial strains; The potential of and essential oils (E.Os) antibacterial and antibiofilm activities in relation to their chemical composition, in addition to their ability to treat wound infection in mice model were investigated; leaf E.O at 0.05 µg·mL efficiently inhibited and eradicated biofilm formed by by 85% and 34%, respectively. Both and leaf E.Os showed a bactericidal action against within 6h at 2.08 µg·mL. In addition, a significant reduction of microbial load in mice wound infection model was found. Furthermore, gas chromatography mass spectrometry analysis revealed qualitative and quantitative differences among and leaf and berry E.Os. Monoterpene hydrocarbons, oxygenated monoterpenes, and phenolics were the major detected classes. β-Myrcene, limonene, 1,8-cineole, and eugenol were the most abundant volatiles. While, sesquiterpenes were found as minor components in berries E.O; Our finding suggests the potential antimicrobial activity of leaf E.O against MDR wound infections and their underlying mechanism and to be further tested clinically as treatment for MDR infections.
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| http://dx.doi.org/10.3390/antibiotics9100679 | DOI Listing |
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