AI Article Synopsis
- - The study investigates D-dimer levels in COVID-19 patients, comparing those with diabetes to those without, given that diabetes is linked to worse outcomes in severe COVID-19 cases.
- - A total of 98 patients were analyzed, revealing that those with diabetes had significantly higher peak D-dimer levels (1509 ng/mL) compared to non-diabetic patients (515 ng/mL).
- - The findings suggest that COVID-19 patients with diabetes may face a greater risk of hypercoagulability and poorer prognosis, but further research is needed to understand the clinical implications of these results.
Article Abstract
Background And Aims: Diabetes is a frequent comorbidity in patients with Severe COVID-19 infection associated with a worse prognosis. Hypercoagulability with elevation in D-dimer levels has been demonstrated in patients with COVID-19. This study aims to study D-dimer levels in people with diabetes compared to those without diabetes among patients with COVID-19 infection.
Methods: In this observational study 98 moderate and severely ill patients with COVID-19 infection were included at a dedicated COVID hospital. The study group was divided into patients with diabetes and without diabetes. Peak D-dimer was measured in both the groups and compared using appropriate statistical tests.
Results: In our study peak D-dimer levels were 1509 ± 2420 ng/mL (Mean ± SD) in people with diabetes and 515 ± 624 ng/mL (Mean ± SD) in patients without diabetes. Patients with diabetes had higher D-dimer levels which were statistically significant.
Conclusions: This study shows COVID-19 patients with diabetes had significantly higher D-dimer levels. Therefore, it is possible that COVID-19 infection with diabetes is more likely to cause hypercoagulable state with a worse prognosis. However clinical implications of these findings will need to be seen in further studies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528836 | PMC |
| http://dx.doi.org/10.1016/j.dsx.2020.09.035 | DOI Listing |
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