AI Article Synopsis
- The study aimed to assess the occurrence of liver neoplasia in dogs with splenic masses by analyzing liver biopsies taken during splenectomy.
- Malignant splenic neoplasia was found in 44.2% of dogs, with a significantly higher incidence of liver neoplasia in those with grossly abnormal livers (28.9%) compared to those with grossly normal livers (2.5%).
- The findings suggest that while liver biopsies from normal-looking livers yield low results, biopsying abnormal livers is advisable post-splenectomy due to the higher likelihood of neoplasia.
Article Abstract
Objective: To determine the prevalence of neoplasia detected on liver biopsy obtained at the time of splenectomy in dogs with splenic masses.
Materials And Methods: Retrospective study of medical records of dogs with splenic masses from which liver biopsies were taken following splenectomy.
Results: Malignant splenic neoplasia was detected in 50 of 113 (44.2%) of the dogs undergoing splenectomy. Neoplastic liver disease was detected on biopsy from 1 of 40 (2.5%) dogs with a grossly normal liver and from 20 of 69 (28.9%) dogs with a grossly abnormal liver. Dogs with a grossly abnormal liver had a ~ 16 times (95% CI: 2.5-170) higher chance of being diagnosed with liver neoplasia on biopsy. Haemoabdomen was also associated with an increased likelihood of liver neoplasia on biopsy at the time of splenectomy.
Clinical Significance: A liver biopsy taken from grossly normal liver is a low-yield diagnostic test but liver biopsy is recommended following splenectomy if the liver appears abnormal at surgery.
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| http://dx.doi.org/10.1111/jsap.13202 | DOI Listing |
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