or mutant MAP2K1 expression in human CB CD34 HSPCs lead to Langerhans cell–like histiocytosis in immune-deficient mice. -expressing human CB CD34 HSPCs did not generate hairy cell leukemia in xenograft mouse models.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556147PMC
http://dx.doi.org/10.1182/bloodadvances.2020001926DOI Listing

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