A bimolecular i-motif mediated FRET strategy was developed based on the proximity-induced folding of two identical cytosine-rich DNA strands. This strategy affords a FRET signal that is highly matched to the dimerization event, and enabled accurate and dynamic in situ imaging of Met homodimerization on a living tumor cell surface.
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Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium.
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Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
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School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P. R. China.
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Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, China.
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Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
Article Synopsis
- * These sensors utilize a new assembly of nucleic acids on cell surfaces, which respond to changes in extracellular pH and potassium levels to release an anticancer drug (AS1411) effectively.
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