The first general method for the synthesis of α-alkyl ynones was developed based on the strategy of electrophilic activation of amides. Its distinctive advantages are attributed to the use of air-stable "bare" 1-copper(I) alkyne as a mild nucleophile without any exogeneous ligand.
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| http://dx.doi.org/10.1021/acs.orglett.0c02944 | DOI Listing |
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